Fig. 1. Representative cases of paramagnetic rim lesions in two MS patients. Subcortical (hollow arrows) and periventricular (hollow arrowheads) lesions of different sizes are observed (A). Subtle and incomplete hypointense rims are observed in SWI. Note the clear and layered paramagnetic rims of MS lesions in QSM images. In another MS patient (B), paramagnetic rims are also observed for small FLAIR lesions in QSM (hollow arrows). In both patients, the T1-weighted black-hole lesion (solid arrows) also shows a QSM rim. Note that while some smaller lesions are paramagnetic, they do not have paramagnetic rims (yellow dotted circles). FLAIR: fluid attenuation inversion recovery, MS: multiple sclerosis, QSM: quantitative susceptibility mapping, SWI: susceptibility-weighted images.
