Table 3. Comparison of follow-up MRI scans in MS and NMOSD patients.
MS | NMOSD | p | |
---|---|---|---|
Number of patients | 22 | 10 | - |
Sex, male:female | 5:17 | 0:10 | 0.264 |
Age, years | 33.2±9.5 | 51.8±13.7 | <0.001 |
Disease duration to first MRI scan, months | 30.9 [4.3–54.4] | 30.2 [0.4–185.2] | 0.617 |
Disease duration to last MRI scan, months | 42.3 [13.0–66.9] | 37.9 [13.4–197.7] | 0.675 |
Follow-up duration, months | 15.8 [10.7–26.4] | 14.2 [9.7–16.6] | 0.204 |
EDSS score | 1.2 [1.0–2.5] | 3.0 [1.5–3.5] | 0.029 |
Per-patient analysis | |||
New T2-weighted lesions | 12/22 (54.5) | 5/10 (50.0) | 1.000 |
New lesions with paramagnetic rims | 8/22 (36.4) | 1/10 (10.0) | 0.266 |
New contrast-enhanced lesions | 5/22 (22.7) | 3/10 (30.0) | 1.000 |
Number of lesions | 12 [6–16] | 8 [3–19] | 0.554 |
Numbers of lesions with paramagnetic rims | 3.5 [1–8] | 0 [0–0] | 0.002 |
Per-lesion analysis | |||
Number of lesions at last MRI scan | 282 | 105 | |
New T2-weighted lesions | 33 (11.7) | 33 (31.4) | <0.001 |
New paramagnetic rims | 19 (6.7) | 19 (18.1) | 0.002 |
Data are mean±standard deviation, n (%), or median [interquartile range] values.
EDSS: Expanded Disability Status Scale, MRI: magnetic resonance imaging, MS: multiple sclerosis, NMOSD: neuromyelitis optica spectrum disorder.