FIGURE 3.

Comparison of signaling pathway and transcription factors between human and mouse TSCs. Wnt and TGF‐β signals are inversely involved in mTSCs and hTSCs. Some of the transcription factors required to maintain mTSCs are not expressed in hTSCs. In mTSCs, Esrrb and Sox2 are known to be activated downstream of FGF signals. ESRRB and SOX2 are not expressed in hTSCs, which is consistent with the FGF‐independent nature of hTSCs. The specific transcription factors for hTSCs are currently unknown