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. 2020 Sep 24;14:548002. doi: 10.3389/fnins.2020.548002

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Copyright © 2020 Tomioka, Nagai and Seki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Behavioral analyses of the three symtptomatic transgenic marmosets. (A) Schematic of symptom progression in the three symtptomatic transgenic marmosets. (B) The levels of body weight gain, (C) spontaneous activity level, and (D) grip strength of three symptomatic transgenic marmosets were significantly lower than those of wild-type marmosets at 5–6 months of age. (E) MRI scanning revealed significant enlargement of the fourth ventricle in the symptomatic transgenic marmoset 1 compared with asymptomatic transgenic marmosets at 13 months of age. (B–E) Adapted and summarized from “Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms” by Tomioka et al. (2017a) with permission.