Table 5.
Targets of THSWD against DR
| UniProt ID | Gene Symbol | Gene Name |
|---|---|---|
| P20248 | CCNA2 | cyclin A2 |
| P12821 | ACE | angiotensin I converting enzyme |
| P09488 | GSTM1 | glutathione S-transferase mu 1 |
| P08473 | MME | membrane metalloendopeptidase |
| P09038 | FGF2 | fibroblast growth factor 2 |
| Q07869 | PPARA | peroxisome proliferator activated receptor alpha |
| P15692 | VEGFA | vascular endothelial growth factor A |
| P04406 | GAPDH | glyceraldehyde-3-phosphate dehydrogenase |
| Q04760 | GLO1 | glyoxalase I |
| P37231 | PPARG | peroxisome proliferator activated receptor gamma |
| P35354 | PTGS2 | prostaglandin-endoperoxide synthase 2 |
| P01112 | HRAS | HRas proto-oncogene, GTPase |
| P29475 | NOS1 | nitric oxide synthase 1 |
| P08069 | IGF1R | insulin like growth factor 1 receptor |
| P30556 | AGTR1 | angiotensin II receptor type 1 |
| P05019 | IGF1 | insulin like growth factor 1 |
| P27361 | MAPK3 | mitogen-activated protein kinase 3 |
| P01375 | TNF | tumor necrosis factor |
| P14780 | MMP9 | matrix metallopeptidase 9 |
| P05091 | ALDH2 | aldehyde dehydrogenase 2 family (mitochondrial) |
| P05121 | SERPINE1 | serpin family E member 1 |
| Q00796 | SORD | sorbitol dehydrogenase |
| P22392 | NME2 | NME/NM23 nucleoside diphosphate kinase 2 |
| P00403 | MT-CO2 | cytochrome c oxidase subunit II |
| Q16698 | DECR1 | 2,4-dienoyl-CoA reductase 1, mitochondrial |
| P14550 | AKR1A1 | aldo-keto reductase family 1 member A1 |
| P09601 | HMOX1 | heme oxygenase 1 |
| P15121 | AKR1B1 | aldo-keto reductase family 1 member B |
| P29474 | NOS3 | nitric oxide synthase 3 |
| Q16539 | MAPK14 | mitogen-activated protein kinase 14 |
| O60218 | AKR1B10 | aldo-keto reductase family 1 member B10 |
| P18031 | PTPN1 | protein tyrosine phosphatase, non-receptor type 1 |
| P55017 | SLC12A3 | solute carrier family 12 member 3 |
| P11226 | MBL2 | mannose binding lectin 2 |
| P21912 | SDHB | succinate dehydrogenase complex iron sulfur subunit B |
| P07339 | CTSD | cathepsin D |
| P17405 | SMPD1 | sphingomyelin phosphodiesterase 1 |
| P14210 | HGF | hepatocyte growth factor |
| P16581 | SELE | selectin E |
| P16109 | SELP | selectin P |
| P09238 | MMP10 | matrix metallopeptidase 10 |
| P08254 | MMP3 | matrix metallopeptidase 3 |
| P12724 | RNASE3 | ribonuclease A family member 3 |
| P08253 | MMP2 | matrix metallopeptidase 2 |
| P35228 | NOS2 | nitric oxide synthase 2 |
| P51606 | RENBP | renin binding protein |
| O60909 | B4GALT2 | beta-1,4-galactosyltransferase 2 |
| P21554 | CNR1 | cannabinoid receptor 1 |
| P13945 | ADRB3 | adrenoceptor beta 3 |
| P08100 | RHO | rhodopsin |
| P01308 | INS | insulin |
| O00206 | TLR4 | toll like receptor 4 |
| Q08209 | PPP3CA | protein phosphatase 3 catalytic subunit alpha |
| P30711 | GSTT1 | glutathione S-transferase theta 1 |
| P19440 | GGT1 | gamma-glutamyltransferase 1 |
| P35968 | KDR | kinase insert domain receptor |
| P35916 | FLT4 | fms related tyrosine kinase 4 |
| P17948 | FLT1 | fms related tyrosine kinase 1 |
| P04049 | RAF1 | Raf-1 proto-oncogene, serine/threonine kinase |
| P42898 | MTHFR | methylenetetrahydrofolate reductase |
| P19838 | NFKB1 | nuclear factor kappa B subunit 1 |
| P20132 | SDS | serine dehydratase |
| P10745 | RBP3 | retinol binding protein 3 |
| P52757 | CHN2 | chimerin 2 |
| P17707 | AMD1 | adenosylmethionine decarboxylase 1 |
| P04179 | SOD2 | superoxide dismutase 2, mitochondrial |
| Q09472 | EP300 | E1A binding protein p300 |