Fig. 2.

Classification of “epigenetic memory” and “reversible” CpGs and DMRs according to their smoking association methylation patterns. Plots of the regression coefficients for CpGs (a) and of the median of CpGs regression coefficients within each DMR (b) representing methylation changes in smokers versus non smokers (x-axis) and former smokers versus non smokers (y-axis). Criteria for classifying CpGs and DMRs as "epigenetic memory" or "reversible" (c). Results were adjusted for child sex, parity, education level, season of conception, study center, maternal body mass index before pregnancy, maternal age at delivery, gestational duration, paternal smoking status at conception, batch, plate and chip, and estimated cellular heterogeneity