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. 2020 Oct 7;11(10):832. doi: 10.1038/s41419-020-2584-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Differentially expressed lncRNAs in HCC samples from circlncRNAnet data (P < 0.05, Log 2 FC > 1) were compared to the data of differentially expressed genes and genes associated with survival in HCC samples from GEPIA2. Intersection of Venn pattern showed that three lncRNAs, LL22NC03-N14H11.1, LINC00152, and RP11-620J15.3 were sorted out. b RT-qPCR data of the levels of three above-mentioned lncRNAs in 62 pairs of HCC tissues and paired non-tumorous ones. c GEPIA data of LL22NC03-N14H11.1 upregulation in LIHC samples and the association of high LL22NC03-N14H11.1 level with low survival in LIHC patients. d RT-qPCR data of LL22NC03-N14H11.1 level in HCC tissues at stage I/II (N = 22) and stage III/IV (N = 40), and in non-metastasis HCC tissues (N = 31) and metastasis HCC tissues (N = 31). e RT-qPCR results of LL22NC03-N14H11.1 level in five HCC cell lines and normal cell line. f Prediction results of lncLocator indicated LL22NC03-N14H11.1 localization mainly in the nucleus. g Subcellular fractionation and FISH staining confirmed that LL22NC03-N14H11.1 was mainly localized in the nucleus in SK-HEP-1 cells. Scale bar: 25 μm. *P < 0.05; **P < 0.01.