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. 2020 Oct 7;11(10):832. doi: 10.1038/s41419-020-2584-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — SK-HEP-1 cells were, respectively, transfected with sh-NC, sh-LL22NC03-N14H11.1#1, or sh-LL22NC03-N14H11.1#1 + sh-LZTR1 and injected subcutaneously or from tail vain to monitor tumorigenesis and metastasis of HCC. a Volumes of xenografts in mice of each group was evaluated every 4 days after subcutaneous injection and the growth curve was outlined. b Twenty-eight days after injection, tumors from each group were resected and weighed. c TUNEL staining was used to evaluate the apoptosis in tumors of each group. d RT-qPCR analysis of LL22NC03-N14H11.1 and LZTR1 in tumors of each group. e Western blot was implemented to detect the levels of LZTR1, c-Myb, H-RAS (G12V), p-ERK1/2, total ERK1/2, p-DRP1 (S616), and total DRP1 in tumors of each group. f, g IHC staining and quantification of Ki67, PCNA, N-cadherin, and E-cadherin in tumors of each group. h Metastatic nodules in tumors of each group was stained by HE and quantified. Scale bar: 100 μm. **P < 0.01; n.s. no significance.