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. 2020 Oct 7;10:16758. doi: 10.1038/s41598-020-73815-5

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Representative images (A, B: 3D Maximal Intensity Projections (MIP) and C–F: trans-axial projection) of PET uptake for the tracer for the GCGR (left panels, A, C, E) and GLP1R (right panels, B, D, F). [⁶⁸Ga]Ga-DO3A-Tuna-2 displayed strong binding in the liver which is rich in GCGR combined with low or negligible uptake in surrounding GCGR negative tissues (A, C). [⁶⁸Ga]Ga-DO3A-Exendin-4 on the other hand showed strong binding to GLP1R in pancreas at baseline (B, D). Both PET tracers were excreted through renal route and trapped in the kidney cortex. The reduction in binding at the follow up examinations following treatment are proportional to the SAR425899 drug occupancy at the respective receptor (E, F). The baseline and follow-up images for the respective tracers are normalized to SUV = 5 and are directly comparable. White arrows indicate liver, yellow arrows indicate pancreas and red arrows indicate kidneys.