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. 2020 Oct 7;10:16756. doi: 10.1038/s41598-020-73802-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phase contrast or immunofluorescent pictures from cell cultures of corrected (A,C,E,G) and MFS (B,D,F,H). hiPSC cultures have similar growth characteristics (A,B) and show expression of pluripotency markers OCT4 (green) and SOX2 (red) and HOECHST (blue) (C,D). Both CMs from corrected and MFS are growing as a layer on top of a basal layer of cells (E,F). The area of CMs in (E) and (F) is highlighted by the dashed line. Passaged CMs show better recovery in corrected (G) compared to MFS CMs (H) as indicated by the more brighter areas in corrected CMs. Scalebars indicate 500 µm. Graph (I) shows the ratio between TNNI3 and TNNI1 as a ratiometric marker for maturation of the CMs at day 15 and day 24, n = 3. Graph (J) represents the relative gene expression for TNNT2 in the cardiac model at day 24 for corrected (black) and MFS (red), n = 6.