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. 2020 Oct 7;10:16756. doi: 10.1038/s41598-020-73802-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MEA measurements of control, corrected and MFS CMs after treatment with serial isoproterenol (ISO) concentrations of 5, 10, 25, 50 and 100 nM. Bar plots show differences between the three lines at each ISO concentration for RR interval (A), SDNN (B), SDSD (C) and the coefficient of variance presented as factor of the baseline (D). The Spearman’s rank correlation is indicated in panel A. Corrected CMs (n = 6, black), MFS CMs (n = 7, red), H9 control (n = 5, blue).