FIGURE 1.

Overview of the subject‐specific musculoskeletal modelling framework. Individualised musculoskeletal geometry (bones and muscle attachment points) for each subject was obtained from digital segmentation of 31 muscles of the lower limb from T1 magnetic resonance images (a–c). Muscle architecture for each muscle was estimated from diffusion tensor imaging (DTI), where fibre orientations can be estimated based on relative water diffusion (d; blue colour represents proximo‐distal fibre orientation, and red represents antero‐posterior orientation). The resulting muscle fibre lengths (e) and muscle volumes (f) were used to calculate maximum isometric force, which were input as force‐generating properties into subject‐specific lower limb musculoskeletal models (g)