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. Author manuscript; available in PMC: 2020 Oct 8.
Published in final edited form as: Int J Cancer. 2012 Oct 17;132(8):1800–1810. doi: 10.1002/ijc.27869

Table 4.

Number of significant CpG target sites being hyper- or hypo-methylated in the different subgroups (aligned to normal mucosa).

Number of significant CpG targets hypermethylation Number of significant CpG targets hypomethylation Sum
HP 48 2 50
Small adenoma (LGD) 3 2 5
Large adenoma (LGD) 73 4 77
Adenoma (HGD) 20 0 20
TSA 125 5 130
SSA/P 110 0 110
MSS CRC 35 5 40
MSI-L CRC 40 2 42
MSI-H CRC 99 7 106
SUM 159 15 174

Abbreviations: HP, hyperplastic polyps; LGD, low grade dysplasia; HGD, high grade dysplasia; TSA, traditional serrated adenoma; SSA/P, sessile serrated adenoma/polyp; CRC, colorectal cancer; MSS, microsatellite stable; MSI-L, low microsatellite instable; MSI-H, high microsatellite instable.