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. 2020 Sep 24;11:532606. doi: 10.3389/fpsyt.2020.532606

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Copyright © 2020 Shaffer, Mani, Schmitz, Xu, Owusu, Wu, Magnotta and Wemmie

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A CEST experiment collected in a human at 7T using an off-resonance RF pulse of B1 = 1.5 µT and a frequency sweep from −6 to 6 ppm with steps of 0.2 ppm. Data were collected using a 3D gradient echo sequence with a TE = 0.5 ms, TR = 3.8 ms. flip angle = 10, FOV = 22 cm × 22 cm × 15 cm, slice thickness=1.0 cm, matrix size = 64 × 64 × 10, NEX = 3.0. (A) Shows the resulting CEST_asym image generated with at Δω at 3.5ppm. The white dot shows a region of interest where the CEST spectrum in (B) was generated. (B) Shows the CEST-spectrum plot in red and the CEST_asym spectrum in blue. The peak of the CEST_asym is at 3.5ppm corresponding to amide proton transfer (APT).