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. 2020 Sep 24;10:599431. doi: 10.3389/fonc.2020.599431

Figure 2.

Figure 2

The overexpression of RTK can activate important mitogenic pathways, including Ras, MAPK, PI3K-Akt, Mtor, and other intracellular signals, which can promote the proliferation of tumor cells. However, PDGFR/EGFR/VEGFR inhibitors can inhibit the activation of RTK, thus reverse this process and lead to tumor cell apoptosis. Chemotherapy drugs such as hydroxyureae and temozolomide can act on cell nucleus, inhibit tumor cells proliferation by inducing cell apoptosis. PDGFR, platelet-derived growth factor receptor; EGFR, epidermal growth factor receptor; VEGFR, vascular endothelial growth factor receptor; RTK, receptor tyrosinekinase; Ras, PI3K, phosphatidylinositol 3-kinase; MAPK, mitogen activated protein kinase; Akt, protein kinase B; mTORC, mammalian target of rapamycin C.