Table 2. Treatment-Related Toxic Effects Compared Between the 2 Groups.
| Toxic effect | No. of patients (%) | P value | |||||||
|---|---|---|---|---|---|---|---|---|---|
| RT (n = 63)a | RT plus icotinib (n = 64) | ||||||||
| Grade 1 | Grade 2 | Grade 3 | Grade 4 | Grade 1 | Grade 2 | Grade 3 | Grade 4 | ||
| Hematologic toxicity | |||||||||
| Neutropenia | 14 (22.2) | 18 (28.6) | 2 (3.2) | 0 | 17 (26.6) | 16 (25) | 2 (3.1) | 0 | .94 |
| Thrombocytopenia | 10 (15.9) | 13 (20.6) | 0 | 0 | 13 (20.3) | 11 (17.2) | 1 (1.6) | 0 | .48 |
| Anemia | 9 (14.3) | 3 (4.8) | 0 | 0 | 8 (12.5) | 3 (4.7) | 0 | 0 | .96 |
| Nonhematologic toxicity | |||||||||
| Radiation esophagitis | 24 (38.1) | 23 (36.5) | 7 (11.1) | 1 (1.6) | 28 (43.8) | 21 (32.8) | 8 (12.5) | 0 | .82 |
| Radiation pneumonitis | 20 (31.7) | 7 (11.1) | 3 (4.8) | 0 | 19 (29.7) | 9 (14.1) | 4 (6.3) | 1 (1.6) | .83 |
| Nausea/vomiting | 20 (31.7) | 5 (7.9) | 0 | 0 | 24 (37.5) | 4 (6.3) | 0 | 0 | .77 |
| ALT/AST elevation | 7 (11.1) | 4 (6.3) | 0 | 0 | 9 (14.1) | 4 (6.3) | 1 (1.6) | 0 | .73 |
| Skin rash | 5 (7.9) | 1 (1.6) | 0 | 0 | 15 (23.4) | 5 (7.8) | 0 | 0 | .01 |
| Diarrhea | 6 (9.5) | 2 (3.2) | 0 | 0 | 9 (14.1) | 4 (6.3) | 0 | 0 | .45 |
Abbreviations: ALT, alanine transaminase; AST, aspartate transaminase; RT, radiation therapy.
a
One patient (1.6%) experienced grade 5 radiation pneumonitis after a radiation of 54 Gy in the RT group.