TABLE 1.
Inhibition of viral replication and NA enzymatic activity of Z2B3 and Z2B3 D102R
| Virus | Inhibition of viral replication (μg/ml) by:a |
Inhibition of enzymatic activity (nM) by:a |
||
|---|---|---|---|---|
| Z2B3 | Z2B3 D102R | Z2B3 | Z2B3 D102R | |
| A/California/07/2009 (H1N1) | 1.432 | 10.94 | 30.41 | 346 |
| A/Puerto Rico/8/1934 (H1N1) | 5.202 | 20.09 | 33.07 | 466.9 |
| A/Serbia/NS-601/2014 (H1N1) | 123.7 | 6.009 | >2,000 | 30.21 |
| A/Vietnam/1194/2004 (H5N1) | 7.883 | 208.3 | 69.73 | 628.4 |
| A/Anhui/1/2013 (H7N9) | 27.27 | 305.6 | 101.3 | 1,878 |
a
Data were shown as IC50 calculated by GraphPad Prism.