Table 1.
Hematological parameters of SD rats orally administered with fermented Citrus Sunki peel extract for 90 days
| Dose of fermented Citrus sunki peel extract (mg/kg) | ||||
|---|---|---|---|---|
| 0 | 500 | 1000 | 2000 | |
| Male (n = 10/group) | ||||
| WBC (103/mm3) | 9.4 ± 2.4 | 8.7 ± 3.8 | 8.4 ± 2.4 | 8.4 ± 1.0 |
| RBC (106/mm3) | 8.1 ± 0.4 | 7.8 ± 0.4 | 8.2 ± 0.3 | 7.8 ± 0.5 |
| HGB (g/dl) | 14.4 ± 0.7 | 13.9 ± 0.7 | 14.6 ± 0.6 | 14.1 ± 0.6 |
| HCT (%) | 39.1 ± 2.0 | 37.6 ± 2.0 | 39.3 ± 1.9 | 35.3 ± 7.6 |
| PLT (103/mm3) | 789.0 ± 84.8 | 768.8 ± 71.4 | 800.2 ± 83.3 | 724.8 ± 57.3 |
| MCV (fl) | 48.3 ± 2.6 | 48.3 ± 1.5 | 47.8 ± 1.2 | 48.8 ± 2.5 |
| MCH (pg) | 17.8 ± 0.8 | 17.9 ± 0.6 | 17.8 ± 0.4 | 18.1 ± 0.9 |
| MCHC (g/dl) | 36.9 ± 0.7 | 37.1 ± 0.6 | 37.2 ± 0.9 | 37.0 ± 0.6 |
| Neutrophils (%) | 11.1 ± 3.1 | 11.1 ± 3.4 | 15.0 ± 4.1* | 12.0 ± 2.4 |
| Eosinophils (%) | 0.30 ± 0.22 | 0.21 ± 0.17 | 0.2 ± 0.09 | 0.15 ± 0.11 |
| Basophils (%) | 0.57 ± 0.14 | 0.50 ± 0.15 | 0.56 ± 0.18 | 0.54 ± 0.16 |
| Lymphocytes (%) | 83.1 ± 3.7 | 83.2 ± 4.0 | 78.5 ± 4.5* | 82.1 ± 3.3 |
| Monocytes (%) | 3.7 ± 0.6 | 3.8 ± 0.7 | 4.5 ± 0.9 | 4.0 ± 1.0 |
| Reticulocytes (%) | 2.7 ± 0.4 | 2.2 ± 0.2* | 2.9 ± 0.6 | 2.4 ± 0.3 |
| PT (sec) | 16.0 ± 0.7 | 15.7 ± 0.5 | 15.7 ± 0.7 | 15.7 ± 0.8 |
| aPTT (sec) | 43.0 ± 7.6 | 44.1 ± 2.0 | 42.7 ± 2.6 | 44.0 ± 4.3 |
| Female (n = 10/group) | ||||
| WBC (103/mm3) | 7.1 ± 1.6 | 6.7 ± 1.7 | 8.0 ± 2.0 | 7.8 ± 3.1 |
| RBC (106/mm3) | 7.2 ± 0.2 | 7.2 ± 0.4 | 7.1 ± 0.4 | 7.0 ± 0.3 |
| HGB (g/dl) | 13.6 ± 0.5 | 13.3 ± 0.3 | 13.3 ± 0.7 | 13.3 ± 0.4 |
| HCT (%) | 36.9 ± 1.1 | 36.2 ± 1.2 | 36.2 ± 2.2 | 36.1 ± 1.2 |
| PLT (103/mm3) | 700.0 ± 93.5 | 705.2 ± 41.3 | 654.3 ± 58.8 | 710.8 ± 48.6 |
| MCV (fl) | 51.5 ± 0.9 | 50.2 ± 1.9 | 50.9 ± 2.0 | 51.3 ± 2.4 |
| MCH (pg) | 19.0 ± 0.7 | 18.5 ± 0.7 | 18.7 ± 0.6 | 18.9 ± 0.7 |
| MCHC (g/dl) | 36.9 ± 1.0 | 36.9 ± 0.9 | 36.8 ± 1.0 | 36.8 ± 0.7 |
| Neutrophils (%) | 7.7 ± 1.4 | 7.4 ± 1.5 | 7.4 ± 2.0 | 8.6 ± 2.9 |
| Eosinophils (%) | 0.12 ± 0.09 | 0.22 ± 0.18 | 0.17 ± 0.12 | 0.22 ± 0.19 |
| Basophils (%) | 0.41 ± 0.10 | 0.47 ± 0.15 | 0.44 ± 0.13 | 0.42 ± 0.08 |
| Lymphocytes (%) | 87.2 ± 2.0 | 87.4 ± 2.0 | 87.4 ± 2.5 | 86.1 ± 3.7 |
| Monocytes (%) | 3.3 ± 0.5 | 3.4 ± 0.5 | 3.5 ± 0.6 | 3.6 ± 0.6 |
| Reticulocytes (%) | 2.0 ± 0.3 | 2.5 ± 0.5* | 2.5 ± 0.4 | 2.2 ± 0.4 |
| PT (sec) | 15.9 ± 0.8 | 16.3 ± 0.5 | 15.9 ± 0.6 | 15.9 ± 0.6 |
| aPTT (sec) | 47.6 ± 5.9 | 49.5 ± 6.4 | 44.8 ± 8.0 | 41.6 ± 7.2 |
WBC white blood cells, RBC red blood cells, Hb hemoglobin, HCT hematocrit, PLT platelet, MCV mean corpuscular volume, MCH mean corpuscular hemoglobin, MCHC mean corpuscular hemoglobin concentration, PT partial thromboplastin time and aPTT activated partial thromboplastin time
*; p < 0.05 by one-way ANOVA followed by post-hoc Dunnet’s test