Table 3.
Absolute and relative organ weight of SD rats orally administered with fermented Citrus sunki peel extract for 90 days
| Dose of fermented Citrus sunki peel extract (mg/kg) | |||||
|---|---|---|---|---|---|
| 0 | 500 | 1000 | 2000 | ||
| Male (n = 10/group) | |||||
| Liver | (g) | 17.1 ± 2.5 | 15.6 ± 1.5 | 15.3 ± 1.4 | 16.1 ± 2.1 |
| (g%) | 2.83 ± 0.12 | 2.73 ± 0.18 | 2.737 ± 0.14 | 2.81 ± 0.18 | |
| Spleen | (g) | 0.94 ± 0.16 | 0.84 ± 0.14 | 0.81 ± 0.09 | 0.87 ± 0.13 |
| (g%) | 0.16 ± 0.02 | 0.15 ± 0.02 | 0.15 ± 0.02 | 0.15 ± 0.02 | |
| Kidney (R) | (g) | 2.02 ± 0.19 | 1.83 ± 0.18 | 1.85 ± 0.17 | 1.90 ± 0.14 |
| (g%) | 0.34 ± 0.02 | 0.32 ± 0.02 | 0.33 ± 0.03 | 0.33 ± 0.03 | |
| Kidney (L) | (g) | 1.99 ± 0.26 | 1.79 ± 0.21 | 1.82 ± 0.16 | 1.92 ± 0.18 |
| (g%) | 0.33 ± 0.02 | 0.31 ± 0.02 | 0.38 ± 0.03 | 0.34 ± 0.02 | |
| Adrenal gl. (R) | (g) | 0.031 ± 0.004 | 0.028 ± 0.003 | 0.029 ± 0.006 | 0.031 ± 0.006 |
| (g%) | 0.005 ± 0.001 | 0.005 ± 0.001 | 0.005 ± 0.001 | 0.005 ± 0.001 | |
| Adrenal gl. (L) | (g) | 0.034 ± 0.006 | 0.029 ± 0.003 | 0.031 ± 0.005 | 0.032 ± 0.005 |
| (g%) | 0.006 ± 0.001 | 0.005 ± 0.001 | 0.006 ± 0.001 | 0.006 ± 0.001 | |
| Testis (R) | (g) | 1.78 ± 0.08 | 1.62 ± 0.16 | 1.70 ± 0.18 | 1.82 ± 0.16 |
| (g%) | 0.30 ± 0.03 | 0.29 ± 0.03 | 0.31 ± 0.05 | 0.32 ± 0.05 | |
| Testis (L) | (g) | 1.80 ± 0.09 | 1.62 ± 0.14* | 1.73 ± 0.20 | 1.82 ± 0.16 |
| (g%) | 0.30 ± 0.03 | 0.29 ± 0.03 | 0.31 ± 0.06 | 0.32 ± 0.05 | |
| Thymus | (g) | 0.28 ± 0.05 | 0.30 ± 0.10 | 0.28 ± 0.06 | 0.24 ± 0.06 |
| (g%) | 0.047 ± 0.009 | 0.054 ± 0.018 | 0.051 ± 0.012 | 0.041 ± 0.009 | |
| Heart | (g) | 1.79 ± 0.14 | 1.62 ± 0.13* | 1.56 ± 0.15* | 1.69 ± 0.16 |
| (g%) | 0.30 ± 0.03 | 0.29 ± 0.02 | 0.28 ± 0.01 | 0.30 ± 0.02 | |
| Lung | (g) | 1.70 ± 0.20 | 1.56 ± 0.05* | 1.55 ± 0.09* | 1.61 ± 0.09 |
| (g%) | 0.28 ± 0.02 | 0.28 ± 0.02 | 0.28 ± 0.02 | 0.28 ± 0.03 | |
| Brain | (g) | 2.22 ± 0.14 | 2.14 ± 0.11 | 2.11 ± 0.09 | 2.16 ± 0.14 |
| (g%) | 0.37 ± 0.05 | 0.38 ± 0.03 | 0.38 ± 0.04 | 0.38 ± 0.03 | |
| Pituitary gl. | (g) | 0.015 ± 0.002 | 0.015 ± 0.002 | 0.013 ± 0.001* | 0.014 ± 0.001 |
| (g%) | 0.002 ± 0.000 | 0.003 ± 0.000 | 0.002 ± 0.000 | 0.002 ± 0.000 | |
| Female (n = 10/group) | |||||
| Liver | (g) | 8.2 ± 1.1 | 9.1 ± 0.9 | 8.6 ± 1.9 | 9.0 ± 1.7 |
| (g%) | 2.74 ± 0.26 | 2.83 ± 0.14 | 2.63 ± 0.33 | 2.88 ± 0.25 | |
| Spleen | (g) | 0.55 ± 0.05 | 0.57 ± 0.08 | 0.57 ± 0.07 | 0.55 ± 0.10 |
| (g%) | 0.18 ± 0.02 | 0.18 ± 0.02 | 0.18 ± 0.03 | 0.18 ± 0.02 | |
| Kidney (R) | (g) | 0.91 ± 0.07 | 0.97 ± 0.06 | 0.98 ± 0.13 | 1.00 ± 0.09 |
| (g%) | 0.30 ± 0.02 | 0.30 ± 0.02 | 0.30 ± 0.02 | 0.32 ± 0.03 | |
| Kidney (L) | (g) | 0.89 ± 0.09 | 0.97 ± 0.04 | 0.98 ± 0.12 | 0.98 ± 0.07* |
| (g%) | 0.30 ± 0.02 | 0.30 ± 0.02 | 0.30 ± 0.02 | 0.32 ± 0.03 | |
| Adrenal gl. (R) | (g) | 0.033 ± 0.003 | 0.037 ± 0.004 | 0.034 ± 0.008 | 0.034 ± 0.005 |
| (g%) | 0.011 ± 0.001 | 0.011 ± 0.001 | 0.010 ± 0.002 | 0.011 ± 0.001 | |
| Adrenal gl. (L) | (g) | 0.037 ± 0.005 | 0.037 ± 0.004 | 0.036 ± 0.009 | 0.037 ± 0.006 |
| (g%) | 0.012 ± 0.002 | 0.011 ± 0.001 | 0.011 ± 0.003 | 0.012 ± 0.001 | |
| Ovary (R) | (g) | 0.060 ± 0.007 | 0.113 ± 0.158 | 0.059 ± 0.010 | 0.061 ± 0.015 |
| (g%) | 0.020 ± 0.003 | 0.038 ± 0.058 | 0.019 ± 0.004 | 0.020 ± 0.005 | |
| Ovary (L) | (g) | 0.058 ± 0.009 | 0.056 ± 0.010 | 0.058 ± 0.013 | 0.058 ± 0.009 |
| (g%) | 0.019 ± 0.003 | 0.018 ± 0.004 | 0.018 ± 0.005 | 0.019 ± 0.004 | |
| Thymus | (g) | 0.25 ± 0.06 | 0.28 ± 0.05 | 0.26 ± 0.07 | 0.29 ± 0.10 |
| (g%) | 0.084 ± 0.018 | 0.088 ± 0.016 | 0.083 ± 0.023 | 0.092 ± 0.023 | |
| Heart | (g) | 0.94 ± 0.09 | 1.05 ± 0.10 | 0.99 ± 0.10 | 0.97 ± 0.10 |
| (g%) | 0.32 ± 0.03 | 0.33 ± 0.03 | 0.31 ± 0.03 | 0.31 ± 0.02 | |
| Lung | (g) | 1.23 ± 0.06 | 1.25 ± 0.16 | 1.26 ± 0.20 | 1.22 ± 0.08 |
| (g%) | 0.41 ± 0.03 | 0.39 ± 0.05 | 0.40 ± 0.08 | 0.40 ± 0.05 | |
| Brain | (g) | 1.92 ± 0.07 | 1.95 ± 0.06 | 1.95 ± 0.09 | 1.90 ± 0.06 |
| (g%) | 0.64 ± 0.04 | 0.61 ± 0.05 | 0.62 ± 0.08 | 0.62 ± 0.08 | |
| Pituitary gl. | (g) | 0.016 ± 0.003 | 0.017 ± 0.002 | 0.018 ± 0.003 | 0.019 ± 0.005 |
| (g%) | 0.005 ± 0.001 | 0.005 ± 0.001 | 0.006 ± 0.001 | 0.006 ± 0.001 | |
*; p < 0.05 by one-way ANOVA followed by post-hoc Dunnett’s test