Fig. 2.

Coverage comparison between EM-seq and WGBS. a Boxplots showing numbers of methylated CG, CHG, and CHH cytosines identified by EM-seq and WGBS. Blue box represents EM-seq and red box represents WGBS. The P values shown at the top were estimated using a Student’s t-test. b Average coverage levels of different dinucleotides in EM-seq and WGBS. c Average coverages of genome-wide 400 bp bins, ranked by GC content, in EM-seq and WGBS. In b and c, coverage levels are normalized with expected coverages (total reads over reference genome). Colored lines represent different library preparations