Fig. 5.

Differences in differentially methylated regions (DMRs) between EM-seq and WGBS. a–c CG (a), CHG (b), and CHH (c) hyper-DMR numbers of pairwise comparison between WGBS and EM-seq from each of the different library preparation conditions. d Total DMR numbers of all EM-seq vs. all WGBS. e Methylation levels of EM-seq and WGBS hyper-DMRs. f GC contents of EM-seq and WGBS hyper-DMRs. In e and f, the P values, shown at the top of the plots, were estimated using a Student’s t-test