Table 1.

Demographics of cohort and healthy controls undertaking the CoRe test. The UKMSR population is shown for comparison.

Characteristic		Total UKMSRa	CoReb cohort (MSc)	CoRe cohort (healthy controls)	Cohort differenced, chi-square test (df)	Cohort differenced, t test (df)	P value
Total participants, n		11,387	102	45	N/Ae	N/A	N/A
Gender, n (% )					0.3 (1)	N/A	.57
	Female	8387 (73.7)	70 (68.6)	28 (62.2)
	Male	3000 (26.3)	32 (31.4)	17 (37.8)
MS type, n (%)					N/A	N/A	N/A
	RRMSf	5988 (52.6)	86 (83.2)	N/A
	PPMSg	1492 (13.1)	5 (5.6)	N/A
	SPMSh	2945 (25.9)	9 (9.3)	N/A
	Other	962 (8.4)	2 (1.9)	N/A
Age (years), mean (SD)		53.6 (11.8)	44.0 (11.0)	38.1 (11.9)	N/A	2.891 (145)	.004
Age at diagnosis (years), mean (SD)		39.2 (10.3)	34.6 (10.6)	N/A	N/A	N/A	N/A
EDSSi, median (range)		6 (0-9.5)	3.5 (1-8)	N/A	N/A	N/A	N/A

^aUKMSR: United Kingdom Multiple Sclerosis Register.

^bCoRe: Cognitive Reaction.

^cMS: multiple sclerosis.

^dDifference between people with multiple sclerosis and healthy controls.

^eN/A: not applicable.

^fRRMS: relapsing-remitting multiple sclerosis.

^gPPMS: primary progressive multiple sclerosis.

^hSPMS: secondary progressive multiple sclerosis.

ⁱEDSS: Expanded Disability Status Score.