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. 2020 Oct 7;10:16671. doi: 10.1038/s41598-020-72978-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Degradation of (a) 4 and (b) 8-arm PEG-collagen hydrogels at different PEG concentrations (4%, 8%, and 16%) 24 h after swelling was evaluated in the presence of 1 mg/mL of collagenase for 12 h. Data is presented as mean ± SD, two-way ANOVA (p < 0.005) was used to detect statistical differences followed by Tukey’s multiple comparisons test. (c) Degradation profile of 4 and 8-arm PEG-collagen in the presence of CSSCs for 12 h. (d) EGF release from 4 and 8-arm PEG-collagen hydrogels during 7 days in PBS. For each condition n = 3 was used.