TABLE 1.

Statistics showing the influences of DNJ on indicated physiological indicators and expression of hepatic genes involved in lipogenesis between male and female mice

Parameter	P value for:				DNJ vs HFD (%)		P valuea
	Male		Female
	HFD vs chow	DNJ vs HFD	HFD vs chow	DNJ vs HFD	Male	Female
Blood parameters
Body wt gain	0.0325	0.2624	0.0004	0.0244	−18.73	−31.17	0.1449
Glucose	0.0000	0.0001	0.0000	0.0000	−25.56	−22.35	0.0067
TG	0.0170	0.0148	0.3274	0.0432	−27.64	−17.25	0.0571
TC	0.0008	0.4844	0.0123	0.0384	−5.21	−21.04	0.0451
LDL-c	0.0131	0.3193	0.0000	0.0004	−12.23	−52.69	0.0000
HDL-c	0.2288	0.6572	0.0009	0.0006	−3.55	54.79	0.0008
Liver TG	0.0000	0.0257	0.0000	0.0059	−11.50	−28.23	0.0000
Liver TC	0.0405	0.1371	0.0167	0.0209	−17.86	−28.75	0.3072
Gene expression
SREBP1c	0.0060	0.0017	0.0000	0.0020	−42.71	−41.26	0.7612
FAS	0.0000	0.0577	0.0000	0.0013	−33.43	−47.62	0.0650
ACC	0.0015	0.0545	0.0000	0.0191	−49.31	−36.85	0.1717
GPAT	0.0188	0.3929	0.0000	0.0118	−21.03	−39.74	0.0615
SCD	0.0441	0.2641	0.0000	0.0052	−34.38	−50.35	0.0542
ChREBP	0.0013	0.1635	0.0002	0.0174	−23.06	−36.64	0.2003
SREBP2	0.0000	0.0610	0.0000	0.0029	−21.30	−30.18	0.0781
HMGR	0.0000	0.8533	0.0000	0.0143	−1.39	−30.07	0.0000
Taxonomic abundances
Clostridium XlVa	0.0544	0.7467	0.0488	0.0157	−4.77	122.52	0.0037
Akkermansia	0.3524	0.4577	0.2083	0.0733	−73.21	9,907.74	0.0514
Metabolite signals
3-Indolepropionic acid	0.0402	0.0282	0.1744	0.0023	159.3053	650.7457	0.0033
N-Acetyl-l-methionine	0.0491	0.8052	0.1023	0.1326	6.7713	−53.1748	0.0178
Hydroxyisobutyrate	0.0029	0.4263	0.0021	0.0604	13.2269	25.5371	0.5223

^aDNJ vs HFD between males and females.