| σ (SFN) |
lung, breast,
uterus, ovary, blood, skin, liver, pancreas, cornea |
•epigenetically
suppressed in epithelial carcinomas |
(9, 28, 31) |
|
•functions
as a tumor suppressor |
| β (YWHAB) |
brain, lung, colon, gastric
lining, liver, bladder, kidney |
•overexpressed
in squamous cell carcinoma |
(28, 35) |
| ε (YWHAE) |
brain (hippocampus),
renal, liver, breast, gastric lining |
•YWHAE
deleted in Miller–Dieker syndrome |
(10, 36) |
|
•found
in Lewy bodies from Parkinson’s patients |
| ζ (YWHAZ) |
brain, breast,
lung, colon, head and neck, oral, ovary, esophagus |
•overexpressed
in cancer and correlates with poor prognosis |
(28, 32, 33) |
|
•found
in NTFs from Alzheimer’s patents; binds to Tau |
| τ (YWAHQ) |
brain (frontal
cortex), breast, lung, prostate |
•overexpression
protects from dopaminergic cell loss |
(10, 34) |
|
•diminished
expression in Alzheimer’s patients |
| η (YWHAH) |
brain (frontal
cortex), liver, lung, prostate |
•binding
to α-synuclein disrupted in Parkinson’s disease |
(10, 34) |
|
•diminished
expression in Alzheimer’s patients |
| γ (YWHAG) |
brain, breast,
liver, lung |
•correlated
with amyotrophic lateral sclerosis (ALS) |
(10, 28, 37) |
|
•overexpressed
in lung cancer; p53 reduces 14-3-3γ mRNA |
