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. Author manuscript; available in PMC: 2020 Oct 8.
Published in final edited form as: Glia. 2018 Oct 30;66(12):2719–2736. doi: 10.1002/glia.23523

FIGURE 13.

FIGURE 13

Prolonged neuroinflammation after TBI (7 dpi) was abrogated by microglial elimination. As above, mice were provided diets formulated with either vehicle or PLX5622 for 14 days and were sham-injured (control) or were subjected to midline fluid percussion injury (TBI). At 7 dpi (21d of Veh or PLX diet), the cortex was dissected, flash-frozen, and RNA was extracted. mRNA copy number of 262 genes was determined by NanoString nCounter mouse inflammation v2 panel plus (n = 4–8). Genes associated with microglia, chemokines/cytokines, injury, complement, or interferon are represented. Data are presented as average copy number ± SEM. Means with (*) are different from Veh-CON (p-adj < .05) and means with means with (#) are significantly different from Veh-TBI (p-adj < .05)