Table 2.

Associations of sustained maternal smoking during pregnancy with newborn DNA methylation, when compared with never smoking

CpG	Mapped gene	Nearest gene (within 10 Mb)	Effect estimate (beta)	Standard error	p-value	p-value (FDR)
cg05575921	AHRR	AHRR	−0.069	0.004	3.57E-71	2.11E-67
cg18316974	GFI1	GFI1	−0.059	0.004	8.69E-37	2.57E-33
cg04180046	MYO1G	MYO1G	0.051	0.004	1.09E-29	2.15E-26
cg12803068	MYO1G	MYO1G	0.068	0.006	4.18E-28	6.18E-25
cg09935388	GFI1	GFI1	−0.083	0.008	1.21E-26	1.43E-23
cg14179389	GFI1	GFI1	−0.064	0.007	5.85E-22	5.77E-19
cg06338710	GFI1	GFI1	−0.044	0.005	2.07E-21	1.75E-18
cg25949550	CNTNAP2	CNTNAP2	−0.023	0.002	3.41E-21	2.52E-18
cg22132788	MYO1G	MYO1G	0.039	0.004	1.45E-19	9.52E-17
cg12876356	GFI1	GFI1	−0.085	0.010	7.68E-18	4.54E-15
cg18146737	GFI1	GFI1	−0.098	0.012	5.35E-16	2.87E-13
cg23067299	AHRR	AHRR	0.033	0.004	1.26E-15	6.21E-13
cg19089201	MYO1G	MYO1G	0.028	0.004	2.97E-15	1.35E-12
cg21161138	AHRR	AHRR	−0.022	0.003	9.93E-14	4.19E-11
cg11902777	AHRR	AHRR	−0.015	0.002	5.28E-13	2.08E-10
cg09662411	GFI1	GFI1	−0.050	0.007	7.81E-12	2.89E-09
cg04598670	—	AUTS2	−0.031	0.005	1.14E-11	3.96E-09
cg08606254	AHRR	AHRR	0.022	0.003	4.62E-11	1.52E-08
cg22549041	CYP1A1	CYP1A1	0.055	0.008	8.46E-11	2.63E-08
cg14817490	AHRR	AHRR	−0.025	0.004	9.16E-11	2.71E-08
cg18703066	—	—	−0.011	0.002	3.15E-10	8.87E-08

Shown are all CpGs with a FDR-corrected p-value of <1E-07 in the main model. Full results are shown in Supplementary Table 3a.