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. 2020 Oct 7;8(2):e000973. doi: 10.1136/jitc-2020-000973

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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Antitumor effects of Amuc and its combination with IL-2 in CT26 tumor-bearing mice. (A) Tumor growth in mice treated with the pasteurized AKK. (B) Tumor growth in mice treated with the culture supernatant of AKK. (C) Tumor growth in mice treated with IL-2 and Amuc. (D) Tumor growth in mice treated with IL-2 and AKK bound with Amuc-specific antibody. (E) Proportions of IFN-γ⁺ CD8⁺ in CD3⁺ T cells in tumor-draining lymph nodes. (F) Proportions of Foxp3⁺ CD25⁺ in CD4⁺ T cells in tumor-draining lymph nodes. (G) Representative flow cytometry analysis of the CTLs in tumor-draining lymph nodes. (H) Representative flow cytometry analysis of Tregs in tumor-draining lymph nodes. All data are shown as mean±SD (n=6) (*p<0.05, **p<0.01). AKK, Akkermansia muciniphila; APC, allophycocyanin; CTL, cytotoxic T lymphocyte; IFN, interferon; IL-2, interleukin-2.