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. 2020 Oct 7;8(2):e001437. doi: 10.1136/jitc-2020-001437

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Estimation of immune cell populations and immune signatures in TCGA-colon cancer. (A) Heatmap showing the estimation of immune cell populations in the TCGA-colon cancer cohort. (B) The ratio of immune cell populations and microsatellite status. The CYT activity (C), IFNG expression (D), TIS score (E), and CD8:Treg ratio (F) in colon cancer with MSS, MSI-L, and MSI-H. The CD274 (G), PDCD1 (H), and CTLA4 (I) expression and exhausted score (J) in colon cancer with MSS, MSI-L, and MSI-H. (K) UMAP clustering of tumor microenvironment cell populations with information regarding cell types from GSE146771. (L) UMAP clustering of tumor microenvironment cell populations with information regarding microsatellite status from GSE146771.