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. 2020 Oct 7;8(2):e001437. doi: 10.1136/jitc-2020-001437

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© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Molecular nature of colon cancer with MSS and MSI. (A) UMAP clustering of B cells, CD4⁺ T cells, CD8⁺ T cells, and malignant cells with information regarding cell types from GSE146771. (B) UMAP clustering of B cells, CD4⁺ T cells, CD8⁺ T cells, and malignant cells with information regarding microsatellite status and cell types from GSE146771. (C) The expression of stemness-related genes in each subgroup of cells. (D) The gene features in each subgroup of cells. (E) The expression of featured genes in CD8⁺ T cells from MSI colon cancer. (F) The expression of featured genes in CD8⁺ T cells from MSS colon cancer. (G) The expression of featured genes in CD4⁺ T cells from MSI colon cancer. (H) The expression of featured genes in CD4⁺ T cells from MSS colon cancer. (I) The ratio of exhausted CD8⁺ T cells and non-exhausted CD8⁺ T cells in colon cancer with MSS and MSI.