Table 1.
Univariate and multivariate Cox regression analyses of the 21-gene signature and OS in the training set (early-stage LUAD)
| Variables | Patients (N) | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|---|
| HR | 95% CI | p value | HR | 95% CI | p value | |||
| GSE30219 | ||||||||
| Age | > 65/ ≤ 65 | 23/59 | 1.765 | 0.946–3.295 | 7.42E−02 | 2.36 | 1.179–4.724 | 1.53E−02 |
| Gender | Male/female | 64/18 | 1.148 | 0.532–2.478 | 7.24E−01 | |||
| T stage | T2/T1 | 12/69 | 2.046 | 1.019–4.107 | 4.40E−02 | 0.982 | 0.352–1.94 | 9.63E−01 |
| Risk score | High/low | 34/48 | 4.308 | 2.287–8.114 | 6.16E−06 | 5.012 | 2.498–10.058 | 5.75E−06 |
| GSE31210 | ||||||||
| Age | > 65/ ≤ 65 | 47/157 | 2.779 | 1.349–5.724 | 5.59E−03 | 3.172 | 1.445–6.964 | 4.01E−03 |
| Gender | Male/female | 95/109 | 1.686 | 0.818–3.476 | 1.57E−01 | 1.033 | 0.347–3.078 | 9.54E−01 |
| Stage | II/I | 42/462 | 4.297 | 2.092–8.828 | 7.21E−05 | 2.444 | 1.152–5.186 | 1.99E−02 |
| Smoking | Yes/no | 99/105 | 1.908 | 0.918–3.966 | 8.35E−02 | 1.726 | 0.565–5.271 | 3.38E−01 |
| ALK fusion | ± | 7/197 | 1.057 | 0.144–7.777 | 9.56E−01 | |||
| EGFR mutation | ± | 116/88 | 0.46 | 0.222–0.956 | 3.76E−02 | 1.658 | 0.512–5.375 | 3.99E−01 |
| KRAS mutation | ± | 19/185 | 0.992 | 0.3–3.282 | 9.89E−01 | |||
| Triple negative | Yes/no | 62/142 | 0.436 | 0.212–0.894 | 2.34E−02 | 0.543 | 0.174–1.698 | 2.94E−01 |
| MYC copy | High/low | 16/187 | 0.767 | 0.183–3.22 | 0.716942752 | |||
| Risk score | High/low | 81/123 | 11.914 | 4.151–34.193 | 4.10E−06 | 8.817 | 2.864–27.14 | 1.48E−04 |
| GSE50081 | ||||||||
| Age | > 65/ ≤ 65 | 87/40 | 1.455 | 0.774–2.735 | 2.44E−01 | |||
| Gender | Male/female | 65/62 | 1.41 | 0.807–2.463 | 2.28E−01 | |||
| Stage | II/I | 35/92 | 2.443 | 1.383–4.316 | 2.10E−03 | 1.905 | 1.068–3.399 | 2.90E−02 |
| T stage | T2/T1 | 82/30 | 2.435 | 1.214–4.883 | 1.22E−02 | 1.625 | 0.785–3.365 | 1.91E−01 |
| Smoking | Yes/no | 92/23 | 1.682 | 0.75–3.776 | 2.07E−01 | |||
| Risk score | High/low | 72/55 | 3.632 | 1.897–6.953 | 9.95E−05 | 2.736 | 1.373–5.455 | 4.24E−03 |
| Combined data set | ||||||||
| Age | > 65/ ≤ 65 | 157/256 | 2.314 | 1.621–3.304 | 3.82E−06 | 2.414 | 1.686–3.456 | 1.49E−06 |
| Gender | Male/female | 224/189 | 1.574 | 1.081–2.291 | 1.80E−02 | 1.582 | 1.084–2.307 | 1.73E−02 |
| Stage | II/I | 90/323 | 2.79 | 1.934–4.026 | 4.08E−08 | 2.065 | 1.42–3.004 | 1.49E−04 |
| Risk score | High/low | 270/143 | 3.153 | 1.981–5.016 | 1.26E−06 | 3.005 | 1.863–4.846 | 6.44E−06 |