Table 1.
Comparison of patients with HRQL decline and without decline in HRQL
| Worsened HRQL in KBILD total score | Without worsening in HRQL | p value | |
|---|---|---|---|
| N | 59 | 135 | |
| FVC% predicted, mean (SD) | 72.4 (21.7) | 75.0 (20.9) | 0.594 |
| DLCO% predicted, mean (SD) | 41.9 (15.8) | 45.7 (16.1) | 0.058 |
| Baseline K-BILD breathlessness and activities, mean (SD) | 48.7 (21.4) | 37.9 (20.0) | 0.001 |
| K-BILD chest symptoms, mean (SD) | 73.5 (23.0) | 57.6 (21.3) | < 0.0001 |
| Baseline K-BILD psychological, mean (SD) | 56.4 (15.3) | 48.7 (12.6) | 0.002 |
| Baseline K-BILD total, mean (SD) | 58.2 (12.7) | 50.4 (11.1) | 0.0002 |
| VAS, mean (SD)a | 60.8 (19.0) | 59.7 (19.8) | 0.743 |
| Mean age, years (SD) | 64.5 (12.8) | 60.5 (12.4) | 0.035 |
| Mean time since diagnosis, years (SD) | 3.5 (3.8) | 4.6 (7.1) | 0.778 |
| Mean number of comorbidities (SD) | 3.1 (1.6) | 2.8 (1.9) | 0.119 |
| Female (%) | 16 (27.1) | 50 (37.0) | 0.180 |
| ILD subtypes | 0.280 | ||
| IPF (%) | 17 (28.8) | 38 (28.2) | |
| Sarcoidosis (%) | 9 (15.3) | 34 (25.2) | |
| Other (%) | 33 (55.9) | 63 (46.7) | |
| Smoking status | 0.929 | ||
| Current (%) | 2 (3.4) | 5 (3.7) | |
| Former (%) | 33 (55.9) | 79 (58.5) | |
| Immunosuppressant medication use (%) | 33 (55.9) | 84 (62.2) | 0.410 |
| Education | 0.517 | ||
| Basic (%) | 24 (40.7) | 56 (41.5) | |
| Secondary (%) | 20 (33.9) | 36 (26.7) | |
| Higher (%) | 15 (25.4) | 43 (31.9) | |
| Employed (%) | 16 (27.1) | 43 (31.9) | 0.510 |
| Center 2 (%) | 48 (81.4) | 77 (57.0) | 0.001 |
aThe complete cases for VAS were 192 and 70 of them had a clinically meaningful decline in HRQL
The figures in italics are results that are statistically significant with p < 0.05