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. 2020 Oct 8;13:137. doi: 10.1186/s13041-020-00675-5

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Distribution of CI-MPR in Glial Cells Derived from iPSCs. a Immunostaining of glial cells for CI-MPR and the Golgi. A proportion of CI-MPR was localized to the perinucleus around the Golgi (Golgi area) in the control group. In the PD group, CI-MPR appeared to accumulate around the Golgi. b Quantification of the results of localization analysis performed in a. The figure shows the intensity of CI-MPR in the cytoplasm (without Golgi area) and Golgi area (n = 3 per line, total n = 69 cells in each group). c Quantification of the results of localization analysis performed in a using the ratio of intensities in the Golgi/cytoplasm (without Golgi) (n = 3 per line, total n = 69 cells in each group). d Immunostaining of iPSC-derived DA neurons (arrow heads) for α-synuclein and TH. e Quantification of the intensity of α-synuclein in the cytoplasm in iPSC-derived DA neurons. The intensity of α-synuclein in the cytoplasm was higher in the PD group than in the control group. (n = 3 per line, total n = 45 cells in Control, n = 39 cells in PD). Data are represented as mean ± SEM; ***P < 0.001; Mann–Whitney U-test in b and c. Scale bars, 10 μm in the upper part of a, 2 μm in the lower part of a and 5 μm in d. See also Additional file 15: Figure S6