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. Author manuscript; available in PMC: 2021 Oct 1.
Published in final edited form as: Drug Alcohol Depend. 2020 Aug 18;215:108235. doi: 10.1016/j.drugalcdep.2020.108235

Figure 4. Effects of mitragynine, 7-hydroxymitragynine, and morphine on brain reward thresholds and response latencies.

Figure 4.

The figures show the effect of mitragynine (A, B), 7-hydroxymitragynine (C, D), and morphine (E, F) on the reward thresholds and latencies for both males and females combined. Plus signs indicate an increase or decrease in the reward thresholds or response latencies compared to rats treated with vehicle. +, p<0.05. ++, p<0.01. A,B: N=18; C,D: N=23; E,F: N=18. Data are expressed as means ± SEM.