Table 1.
Clinical Characteristics by Tumor Gradea
| Characteristic | All (n = 46) | Grade 1 (n = 36) | Grade 2 (n = 10) |
|---|---|---|---|
| Age at diagnosis, years | 9.5 (4.8–12) | 10 (6–12.2) | 5 (4.1–11.1) |
| Male | 27 (59%) | 20 (56%) | 7 (70%) |
| Diagnosis | |||
| Astrocytoma | 13 (28%) | 6 (17%) | 7 (70%) |
| Ganglioglioma | 4 (9%) | 4 (11%) | 0 (0%) |
| Gemistocitic astrocytoma | 1 (2%) | 0 (0%) | 1 (10%) |
| Glioneuronal tumor | 1 (2%) | 0 (0%) | 1 (10%) |
| Low-grade glioma with pilocytic/pilomyxoid features | 1 (2%) | 1 (3%) | 0 (0%) |
| Pilocytic astrocytoma | 26 (57%) | 25 (69%) | 1 (10%) |
| Region of spine | |||
| Cervical | 13 (28%) | 12 (33%) | 1 (10%) |
| Cervical/thoracic | 17 (37%) | 12 (33%) | 5 (50%) |
| Thoracic | 11 (24%) | 9 (25%) | 2 (20%) |
| Thoracic/lumbar | 5 (11%) | 3 (8%) | 2 (20%) |
| Treatment (surgery) | |||
| Gross total resection | 6 (13%) | 6 (17%) | 0 (0%) |
| Near total resection | 2 (4%) | 2 (6%) | 0 (0%) |
| Subtotal resection | 38 (83%) | 28 (78%) | 10 (100%) |
| Chemotherapy | 23 (50%) | 17 (47%) | 6 (60%) |
| Radiation | 8 (17%) | 7 (19%) | 1 (10%) |
| BRAF fusion (N = 31) | 13 (42%) | 12 (52%) | 1 (12%) |
| Clinical outcomes | |||
| Relapse | 17 (37%) | 13 (36%) | 4 (40%) |
| Months to relapse | 11 (3–24) | 14 (4–26) | 7 (3–14) |
| Death | 7 (15%) | 6 (17%) | 1 (10%) |
| Months to death | 26 (17–40) | 23 (15–41) | 34 (34–34) |
aNumbers reported are median (interquartile range) or count (proportion).