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. 2020 Mar 23;26(11):1281–1297. doi: 10.1177/1352458520907901

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© The Author(s), 2020

This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 3. — (a) Forest plot of studies examining the relationship between previous infectious mononucleosis and MS. (b) Funnel plot demonstrating no clear evidence of publication bias in these studies. (c) Forest plot demonstrating OR_MS for HLA⁺IM⁺ persons. (d) Forest plot demonstrating OR_MS for HLA^–IM⁺ persons. (e) Forest plot demonstrating OR_MS for HLA⁺IM^– persons. (f) Bar chart demonstrating lack of evidence of interaction between HLA-DRB1*1501 genotype and prior IM on an additive, but not multiplicative scale. The dotted line represents the null (OR = 1). (g)–(j) Forest plots demonstrating estimates of interaction – AP, RERI, synergy index, and multiplicative interaction respectively – for studies with individual-level data available. The reference group (with OR = 1) is HLA^–IM^– individuals for all panels. MIT: multiplicative interaction term.