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Favipiravir (T-705) effectively reduces footpad swelling in CHIKV-infected mice at doses of 400 mg/kg/d (A-E), while it is less effective at a dose of 100 mg/kg/d (F-J). There appeared to be equivalent efficacy in mice infected with LR06, SEN, or NGR. Footpad swelling (A-C, F-H), viremia (D, I) and virus titer in the hind limb on 6 dpi (E, J) were used as disease parameters (***P<0.001, **P<0.01, *P<0.05 as compared with virus infection controls).
