Table 1.
Results of the GO and KEGG functional enrichment analysis for the target genes of differentially expressed miRNAs.
| ID | Description | No. | p-value | Adjusted p-value | Gene symbol |
|---|---|---|---|---|---|
| Biological process (significant) | |||||
| GO: 0045475 | Locomotor rhythm | 4 | 5.84 × 10−6 | 0.017 | MTOR, ID2, PTEN, ZFHX3 |
| GO: 0006367 | Transcription initiation from RNA polymerase II promoter | 9 | 1.83 × 10−5 | 0.024 | RBPJ, NRBP1, RORA, RXRB, ESR1, NR3C1, TAF12, PTEN, PPARGC1A |
| GO: 0006352 | DNA-templated transcription, initiation | 10 | 2.39 × 10−5 | 0.024 | RBPJ, NRBP1, RORA, RXRB, ESR1, NR3C1, TAF12, PTEN, SMARCA5, PPARGC1A |
| GO: 0007569 | Cell aging | 7 | 5.23 × 10−5 | 0.033 | CDK6, MTOR, SERPINE1, VASH1, ID2, NAMPT, PTEN |
| GO: 0045445 | Myoblast differentiation | 6 | 6.23 × 10−5 | 0.033 | AKIRIN1, RBPJ, BTG1, MBNL1, ID3, SMYD1 |
| GO: 0046777 | Protein autophosphorylation | 9 | 6.67 × 10−5 | 0.033 | MTOR, FGFR3, LYN, WNK3, MARK2, MINK1, TAOK1, PDGFB, CSF1R |
| GO: 0016358 | Dendrite development | 9 | 8.28 × 10−5 | 0.035 | TIAM1, MTOR, PICALM, FSTL4, CRKL, MINK1, PTEN, PACSIN1, SDK1 |
| GO: 0019216 | Regulation of lipid metabolic process | 12 | 1.38 × 10−4 | 0.042 | RORA, MTMR3, MTOR, SP1, FGFR3, LYN, ID2, CHD9, SF1, PDGFB, CREBL2, PPARGC1A |
| GO: 0048511 | Rhythmic process | 10 | 1.47 × 10−4 | 0.042 | RORA, MTOR, ESR1, SP1, SERPINE1, ID2, NAMPT, PTEN, ZFHX3, PPARGC1A |
| GO: 0032922 | Circadian regulation of gene expression | 5 | 1.52 × 10−4 | 0.042 | RORA, ID2, NAMPT, ZFHX3, PPARGC1A |
| GO: 0050773 | Regulation of dendrite development | 7 | 1.63 × 10−4 | 0.042 | TIAM1, MTOR, FSTL4, CRKL, PTEN, PACSIN1, SDK1 |
| GO: 0001933 | Negative regulation of protein phosphorylation | 12 | 1.90 × 10−4 | 0.042 | PPP1R15B, UBE2B, RGS2, MTOR, TRIB2, MLLT1, LYN, CTDSPL, CRKL, DDIT4, PTEN, PPARGC1A |
| GO: 0033002 | Muscle cell proliferation | 9 | 2.02 × 10−4 | 0.042 | AKIRIN1, RBPJ, MTOR, ID2, NAMPT, SF1, PTEN, PDGFB, PPARGC1A |
| GO: 0014812 | Muscle cell migration | 6 | 2.21 × 10−4 | 0.042 | AKIRIN1, SERPINE1, ARPC5, PDGFB, PPARGC1A, NET1 |
| GO: 0021542 | Dentate gyrus development | 3 | 2.38 × 10−4 | 0.042 | CDK6, BTG2, PTEN |
| GO: 0021761 | Limbic system development | 6 | 2.58 × 10−4 | 0.042 | CDK6, YWHAE, BTG2, CRKL, ARPC5, PTEN |
| GO: 0002573 | Myeloid leukocyte differentiation | 8 | 2.82 × 10−4 | 0.042 | AKIRIN1, RBPJ, MTOR, ID2, NAMPT, SF1, PTEN, PDGFB, PPARGC1A |
| GO: 0007623 | Circadian rhythm | 8 | 2.82 × 10−4 | 0.042 | RORA, MTOR, SERPINE1, ID2, NAMPT, PTEN, ZFHX3, PPARGC1A |
| GO: 0010810 | Regulation of cell-substrate adhesion | 8 | 2.82 × 10−4 | 0.042 | CDK6, OLFM4, SERPINE1, RCC2, CRKL, SDC4, MINK1, PTEN |
| GO: 1901861 | Regulation of muscle tissue development | 7 | 2.83 × 10−4 | 0.042 | AKIRIN1, RBPJ, ERBB3, RGS2, MTOR, PTEN, PPARGC1A |
| GO: 0060998 | Regulation of dendritic spine development | 5 | 3.12 × 10−4 | 0.044 | TIAM1, MTOR, FSTL4, PTEN, SDK1 |
| KEGG pathways (top 15) | |||||
| hsa04151 | PI3K-Akt signaling pathway | 12 | 7.98 × 10−5 | 0.014 | CDK6, ERBB3, MTOR, YWHAE, FGFR3, PPP2R1B, YWHAZ, DDIT4, PTEN, PDGFB, CSF1R, CRTC2 |
| hsa05202 | Transcriptional misregulation in cancer | 8 | 2.84 × 10−4 | 0.022 | RUNX1, RXRB, H3F3B, SP1, MLLT1, ID2, MAX, CSF1R |
| hsa05224 | Breast cancer | 7 | 3.77 × 10−4 | 0.022 | CDK6, FRAT2, MTOR, ESR1, SP1, FZD6, PTEN |
| hsa01521 | EGFR tyrosine kinase inhibitor resistance | 5 | 7.57 × 10−4 | 0.033 | ERBB3, MTOR, FGFR3, PTEN, PDGFB |
| hsa04390 | Hippo signaling pathway | 6 | 2.81 × 10−3 | 0.097 | YWHAE, SERPINE1, PPP2R1B, ID2, FZD6, YWHAZ |
| hsa05230 | Central carbon metabolism in cancer | 4 | 3.61 × 10−3 | 0.105 | MTOR, FGFR3, SLC7A5, PTEN |
| hsa05214 | Glioma | 4 | 4.87 × 10−3 | 0.121 | CDK6, MTOR, PTEN, PDGFB |
| hsa03018 | RNA degradation | 4 | 5.86 × 10−3 | 0.127 | BTG1, BTG2, EDC3, PABPC1L2B |
| hsa05206 | MicroRNAs in cancer | 8 | 7.26 × 10−3 | 0.135 | CDK6, ERBB3, MTOR, FGFR3, CRKL, DDIT4, PTEN, PDGFB |
| hsa04550 | Signaling pathways regulating pluripotency of stem cells | 5 | 9.10 × 10−3 | 0.135 | FGFR3, ID3, ID2, FZD6, ZFHX3 |
| hsa05222 | Small cell lung cancer | 4 | 9.97 × 10−3 | 0.135 | CDK6, RXRB, MAX, PTEN |
| hsa05203 | Viral carcinogenesis | 6 | 1.01 × 10−2 | 0.135 | RBPJ, CDK6, YWHAE, LYN, HLA-A, YWHAZ |
| hsa04350 | TGF-beta signaling pathway | 4 | 1.07 × 10−2 | 0.135 | SP1, PPP2R1B, ID3, ID2 |
| hsa05205 | Proteoglycans in cancer | 6 | 1.09 × 10−2 | 0.135 | TIAM1, ERBB3, MTOR, ESR1, FZD6, SDC4 |
| hsa04015 | Rap1 signaling pathway | 6 | 1.24 × 10−2 | 0.142 | TIAM1, FGFR3, CRKL, PDGFB, CSF1R, CTNND1 |
miRNA, microRNA; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes.