Table 2.
Results of Association Between High NORAD Expression and Characteristics of Cancer Patients.
| Stratified analysis | No. of studies | No. of patients | Test of association | Test of heterogeneity | |||
|---|---|---|---|---|---|---|---|
| Pooled HR/OR 95% CI | p-value | I2 (%) | p-value | Model | |||
| OS | 8 | 517 | 1.67 (1.44, 1.95) | < 0.00001 | 48 | 0.06 | Fixed |
| Subgroup analysis of OS on HR availability | |||||||
| MA | 3 | 291 | 1.83 (1.12, 3.02) | 0.02 | 73 | 0.02 | Random |
| SC | 5 | 226 | 1.85 (1.49, 2.29) | < 0.00001 | 11 | 0.34 | Fixed |
| Age (young vs ≥ old) | 8 | 550 | 0.93 (0.63, 1.36) | 0.71 | 14 | 0.32 | Fixed |
| Gender (male vs. female) | 6 | 453 | 1.31 (0.84, 2.02) | 0.23 | 0 | 0.57 | Fixed |
| Tumor size (small vs large) | 8 | 550 | 1.19 (0.47, 2.59) | 0.83 | 81 | < 0.00001 | Random |
| Tumor grade (poor vs well+moderate) | 4 | 340 | 1.61 (1.01, 2.56) | 0.05 | 48 | 0.12 | Fixed |
| Tumor stage (high vs low) | 7 | 500 | 1.18 (0.45, 3.11) | 0.74 | 83 | < 0.00001 | Random |
| LNM (yes vs no) | 5 | 336 | 2.66 (1.60, 4.43) | 0.0002 | 47 | 0.11 | Fixed |
HR: hazard ratios; OR: odds ratios; CI: confidence intervals; OS: overall survival; MA: multivariate analysis; SC: survival curve; LNM: lymph node metastasis.