Table 2.

Results of subgroup analyses.

Analysis	Sensitivity (95%CI)	Specificity (95%CI)	PLR (95%CI)	NLR (95%CI)	DOR (95%CI)
Control source
Healthy	0.91 (0.86–0.94)	0.84 (0.72–0.92)	5.7 (3.0–10.7)	0.11 (0.07–0.17)	51 (21–124)
HCV	0.86 (0.78–0.92)	0.87 (0.79–0.92)	10.31 (1.09–97.52)	0.17 (0.11–0.26)	54.26 (14.59–83.44)
HCV-related  cirrhosis	0.81 (0.76–0.86)	0.77 (0.69–0.84)	3.74 (2.64–5.22)	0.23 (0.17–0.31)	16.83 (9.71–29.19)
Sample type
Serum	0.87 (0.82–0.90)	0.85 (0.77–0.90)	5.60 (3.70–8.60)	0.16 (0.12–0.22)	34 (19–67)
Plasma	0.93 (0.8–0.98)	0.75 (0.59–0.87)	3.57 (2.08–6.13)	0.11 (0.04–0.33)	33.7 (8.41–135.08)
Sample size
≤100	0.88 (0.83–0.91)	0.85 (0.76–0.91)	5.90 (3.50–9.70)	0.14 (0.10–0.20)	41 (20–85)
>100	0.85 (0.81–0.89)	0.81 (0.75–0.87)	4.54 (3.33–6.18)	0.81 (0.09–0.34)	26.28 (13.96–49.48)
Overall	0.87 (0.83–0.90)	0.83 (0.77–0.88)	5.1 (3.7–7.0)	0.16 (0.12–0.21)	32 (19–54)

CI, confidence interval; DOR, diagnostic odds ratio; NLR, negative likelihood ratio; PLR, positive likelihood ratio.