Table 3.
Multivariate analyses for disease‐free survival and overall survival
| Disease‐free survival | Overall survival | |||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| HER2 | ||||
| Negative | 1 | — | — | |
| Positive | 2.512 (1.232–5.125) | .011 | ||
| Nodal stage | ||||
| N0 | 1 | 1 | ||
| N1/Nx | 2.969 (1.705–5.170) | .00012 | 3.516 (1.864–6.633) | .0001 |
| Resection margin | ||||
| R0 | 1 | 1 | ||
| R1/R2 | 2.503 (1.109–5.651) | .027 | 1.826 (0.857–3.892) | .119 |
| Tumor site | ||||
| Intrahepatic | 1 | .030 | 1 | .004 |
| Ampullary | 0.347 (0.165–0.728) | .005 | 0.235 (0.095–0.583) | .002 |
| Gallbladder | 0.882 (0.380–2.045) | .77 | 1.571 (0.716–3.451) | .260 |
| Extrahepatic | 1.017 (0.576–1.794) | .954 | 0.984 (0.504–1.922) | .963 |
| ECOG PS | ||||
| 0/1 | — | — | 1 | |
| >1 | 2.933 (1.140–7.86) | .026 | ||
| Lymphadenectomy | ||||
| No | — | — | 1 | |
| Yes | 0.876 (0.621–1.237) | .453 | ||
ECOG PS and lymphadenectomy were not tested in the multivariate model for disease‐free survival because significance was not reported at univariate analysis (as was for HER2 status in the multivariate model for overall survival).
Abbreviations: —, not performed; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; HR, hazard ratio.