Table 2.

Baseline characteristics and OS in the three different groups of bevacizumab exposure

Characteristic	Ctm ≤41.9 mg/L	Ctm 43–87.2 mg/L	Ctm ≥87.9 mg/L	p value
Median age, years	63.3	63.4	61.3	.89
Sex (males)	73%	60%	50%	.56
KRAS (mutant)	57%	55%	33%	.77
Median OS (range), months	12.8 (7.7–17.9)	36 (23.4–48.5)	N/A	.0003

Median OS was not reached for the high exposure group.

Bolded p value is statistically significant.

Abbreviations: C_tm, median bevacizumab trough concentration at steady state; N/A, not applicable; OS, overall survival.