Table 1.
Characteristics | n (%) |
---|---|
No. of patients | 81 |
Age, median (range), yr | 39 (21–78) |
Male vs. female | 41 vs. 40 |
Stage I–II | 23 (28) |
Stage III–IV | 58 (72) |
No. of therapies before CBT, median (range) | 4 (1–11) |
No. of SCTs prior to CBT | 40 (49) |
Auto | 31 |
Allo | 6 |
Both (with allo most recent) | 3 |
Disease status prior to CBT | |
Relapsed (responded for more than 6 mo) | 22 |
Refractory (progressed within 6 mo) | 59 |
DOR to most recent treatment prior to CBT, median (range), days | 84 (0–2,953) |
No. of CBT infusions, median (range) | 8 (1–41) |
Best response to CBT | |
PD | 17 (21) |
SD | 18 (22) |
PR | 38 (47) |
CR | 7 (9) |
Indeterminate | 1 (1) |
Reason for discontinuing CBT | |
PD | 53 (65) |
Toxicity | 13 (16) |
Transplant prep | 10 (12) |
Infection | 1 |
Per protocol | 1 |
CR after adding chemo | 1 |
CR to CBT but PD after discontinuation | 2 |
DOR to post‐CBT therapy, median (range), days | 169 (30–1,490) |
Time between CBT and subsequent treatment, median (range), days | 47 (0–737) |
No. of SCTs after CBT | 38 (47) |
Auto | 16 |
Allo | 22 |
Abbreviations: Allo, allogeneic; Auto, autologous; CBT, checkpoint blockade; CR, complete response; DOR, duration of response; PD, progression of disease; PR, partial response; SCT, stem cell transplant; SD, stable disease.