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The kinetics of MDZ 4-hydroxylation by HLMs or by recombinant CYP3A4 or CYP3A5 Supersomes were described best by a simple unienzyme Michaelis-Menten model. Berberine acted as a noncompetitive inhibitor of CYP3A4 and HLM-mediated MDZ 4-hydroxylation as well as a mixed inhibitor of this reaction when catalyzed by CYP3A5 (Tables 2–4).
