Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
CBD inactivation kinetics of select CYPs in HLMs
Data represent means ± S.D. of four independent experiments.
| Enzyme | KI (μM) | KI,u (μM) | kinact (min−1) | kinact/KI,u (min−1 μM−1) |
|---|---|---|---|---|
| CYP1A2 | 0.95 ± 0.42 | 0.11 ± 0.05 | 0.07 ± 0.01 | 0.70 ± 0.34 |
| CYP2C19 | 3.33 ± 2.01 | 0.40 ± 0.24 | 0.04 ± 0.01 | 0.11 ± 0.06 |
| CYP3A | 4.83 ± 2.10 | 0.58 ± 0.25 | 0.08 ± 0.02 | 0.14 ± 0.04 |
