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. 2020 Sep 27:ehaa697. doi: 10.1093/eurheartj/ehaa697

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.

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(A) Estimated difference of soluble angiotensin-converting enzyme 2 (sACE2) based on the models with clinical variables and treatments for ARISTOTLE (left panel) and RE-LY (right panel). (B) Estimated difference of sACE2 based on the models with clinical variables, treatments, and biomarkers for ARISTOTLE (left panel) and RE-LY (right panel). Unadjusted results (grey, open circles) and adjusted results (black, filled circles). Variables are sorted after estimated effect size in ARISTOTLE. Note that effect sizes for continuous variables are, for a comparison between the third and the first quartile in both studies, estimated using only the ARISTOTLE data. ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; TIA, transient ischaemic attack; BMI, body mass index. NT-proBNP, N-terminal probrain natriuretic peptide; cTnT-hs, high-sensitive cardiac troponin T; GDF-15, growth differentiation factor 15.