Table 3.
Overall ECG data analysis
| Per group comparisons |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (n = 649) | ECG at T1 (n = 358) | ECG at T2 (n = 404) | T0–T1P | Mean Δ | T0–T2P | Mean Δ | T1–T2P | Mean Δ | ||
| Heart rate (b.p.m.), median (IQR) | 78(68–89) | 75(65–82) | 74(65-82) | <0.001 | –3.3(–4.9 to –1.7) | <0.001 | –5.0(–6.8 to –3.2) | 0.287 | ||
| Rhythm Sinus, n (%) Atrial fibrillation/flutter, n (%) | 610 (94.0) 39 (6.0) | 337 (94.1) 21 (5.9) | 372 (92.1) 32 (7.9) | 0.401 | ||||||
| PQ interval (ms), median (IQR) | 160(140–176) | 160(140–180) | 160(150–180) | 0.287 | ||||||
| QRS width (ms), median (IQR) | 90(81–100) | 90(82–100) | 90(84–100) | 0.259 | ||||||
| QT interval (ms), median (IQR) | 380(356–400) | 395(370–415) | 400(370–420) | <0.001 | +13(+10 to +17) | <0.001 | +20(+16 to +23) | <0.001 | +9(+4 to +13) | |
| QTc Bazett (ms), median (IQR) | 431(410–452) | 436(416–459) | 438(417–462) | 0.478 | <0.001 | +9(+4 to +12) | <0.001 | +8(+3 to +12) | ||
| QTc Fridericia (ms), median (IQR) | 411(392–432) | 421(404–440) | 423(406–442) | 0.004 | +8(+5 to +12) | <0.001 | +13(+9 to +16) | <0.001 | +8(+4 to +12) | |
| QTc Framingham (ms), median (IQR) | 411 (393–431) | 421(405–440) | 422(407–441) | 0.003 | +8(+5 to +11) | < 0.001 | +12(+9 to +15) | < 0.001 | +7(+3 to+10) | |
Δ, difference.
P-values of significance are reported for direct comparisons among groups only in the case of an overall all-comparison significant P. The reported level of significance is assessed after adequate post-hoc comparison corrections.