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. 2020 Sep 24;11:577628. doi: 10.3389/fpsyt.2020.577628

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Copyright © 2020 Ballard, Gilbert, Fields, Nugent and Zarate

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modulatory and Group Effects. (A) Parametric Empirical Bayesian (PEB) analysis identified modulations on the forward connections from early visual cortex (EV) to amygdala (AM) based on trial type; increased connectivity was found for self-death compared with self-life trials across participants for both superficial pyramidal (SP) to spiny stellate (SS) cell and SP to deep pyramidal (DP) cell connections. (B) PEB also identified significant group differences in connectivity between healthy volunteer (HV) and suicide crisis (SC) participants for both the forward connection between EV and insula (IN) carried via superficial pyramidal cells to SS cells and the backward connection from AM to EV carried by DP to SP cells.