Table 1.

Parameters mediating the average effect and difference between groups.

	Parameter	Parameter Estimate (Ep)	Posterior Probability (Pp)
Average Effects
1	Forward Connection (SP to SS)—EV to AM	−0.3035	1
2	Forward Connection (SP to DP)—EV to AM	−0.2287	1
3	Trial Modulation – Forward Connections—EV to AM	−0.4451	1
4	Backward Connection (DP to SP)—IN to EV	0.144	0.6059
5	Backward Connection (DP to SP)—IN to AM	0.0695	0.505
6	Forward Connection (SP to SS)—EV to IN	−0.0696	0.503
7	Forward Connection (SP to SS)—AM to IN	−0.0833	0.502
Group Differences
1	Forward Connection (SP to SS)—EV to IN	−0.5904	1
2	Backward Connection (DP to SP)—AM to EV	0.5477	1
3	Backward Connection (DP to II)—IN to EV	0.247	0.54
4	Backward Connection (DP to II)—AM to EV	0.2341	0.528
5	Backward Connection (DP to SP)—IN to EV	0.1824	0.521
6	Backward Connection (DP to SP)—IN to AM	−0.1708	0.504

Parametric empirical Bayes was used to identify the mixing of parameters that contributed to both the average effect across participants and the difference between groups (healthy volunteers (HVs) versus participants experiencing a suicide crisis (SC)). Meaningful parameters were defined as those with a posterior probability (Pp) of greater than 0.95. Significant effects across participants were found on the forward connections between early visual cortex (EV) and amygdala (AM), carried by superficial pyramidal cells (SPs) to both spiny stellate cells (SSs) and deep pyramidal cells (DPs). Significant trial modulations (i.e., self-death versus self-life) across participants were also found on the forward connections from EV to AM. Significant group differences were found on the forward connections from EV to insula (IN) carried by SP to SS cells, and on the backward connections from AM to EV carried by DP to SP cells. II=inhibitory interneurons.