Table 1.
Patient characteristics
| Irradiation-sparing cohort (n = 28) | SHH subgroup (n = 16) | Group 3 subgroup (n = 3) | Group 4 subgroup (n = 9) | |
|---|---|---|---|---|
| Age (years) | ||||
| Median | 2.16 | 1.65 | 2.6 | 5.97 |
| Range | 0.24–9.82 | 0.24–4.45 | 1.02–2.68 | 2.71–9.82 |
| n (%) | n (%) | n (%) | n (%) | |
| Race/ethnicity | ||||
| White | 7 (25) | 3 (18.7) | 1 (33.3) | 3 (33.3) |
| Hispanic/latino | 18 (64.3) | 11 (68.7) | 1 (33.3) | 6 (66.7) |
| Asian | 3 (10.7) | 2 (12.5) | 1 (33.3) | 0 |
| Disease stage | ||||
| M0 | 18 (64.3) | 13 (81.2) | 1 (33.3) | 4 (44.4) |
| M1 | 2 (7.1) | 1 (6.2) | 1 (33.3) | 0 |
| M2 | 1 (3.6) | 0 | 1 (33.3) | 0 |
| M3 | 7 (25) | 2 (12.5) | 0 | 5 (55.6) |
| Extent of resection | ||||
| GTR | 20 (71.4) | 11 (68.8) | 3 (100) | 6 (66.7) |
| NTR | 3 (10.7) | 1 (6.2) | 0 | 2 (22.2) |
| STR | 5 (17.9) | 4 (25.0) | 0 | 1 (11.1) |
| Histology | ||||
| Desmoplastic/nodular | 8 (28.6) | 8 (50) | 0 | 0 |
| Classic | 15 (53.6) | 8 (50) | 1 (33.3) | 6 (66.7) |
| Large cell/anaplastic | 5 (17.8) | 0 | 2 (66.7) | 3 (33.3) |
| Treatment regimen | ||||
| High-dose chemo | 17 (60.7) | 11 (68.8) | 1 (33.3) | 5 (55.5) |
| Conventional chemo | 11 (39.3) | 5 (31.2) | 2 (66.7) | 4 (45.5) |
| Radiation therapy | ||||
| At disease recurrence | 6 (100) | 3 | 0 | 3 |